Helena Posteri

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1<i>H</i>-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Gianluca Papeo, Helena Posteri, Daniela Borghi et al. · Journal of Medicinal Chemistry · 2015 · 139 citations · Full text

Cancer Therapy, Drug Target, Pharmacotherapy +18

NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor

Italo Beria, R Bossi, Maria Gabriella Brasca et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 104 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +9

Identification of 4,5-Dihydro-1<i>H</i>-pyrazolo[4,3-<i>h</i>]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Italo Beria, Dario Ballinari, J. A. Bertrand et al. · Journal of Medicinal Chemistry · 2010 · 80 citations · Full text

Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors

Marina Caldarelli, Mauro Angiolini, Teresa Disingrini et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 49 citations · Full text

Medicinal Chemistry, Medicine, Drug Discovery +8

Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515

Gianluca Papeo, Paolo Orsini, Nilla Avanzi et al. · ACS Medicinal Chemistry Letters · 2019 · 42 citations · Full text