NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

Barbara Valsasina, Italo Beria, Cristina Alli, +21

Molecular Cancer Therapeutics

Bipolar Spindle FormationAntitumor ActivityCell DeathCell CycleTumor Biology +15

NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor

Italo Beria, R Bossi, Maria Gabriella Brasca, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +7

Identification of 4,5-Dihydro-1<i>H</i>-pyrazolo[4,3-<i>h</i>]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Italo Beria, Dario Ballinari, J. A. Bertrand, +21

Journal of Medicinal Chemistry

Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo.

Ulisse Cucchi, Laura Gianellini, Anna De Ponti, +11

PubMed

Molecular RegulationCell DeathPathologyCellular PhysiologyTumor Biology +19

Synthesis and Antitumor Activity of New Benzoheterocyclic Derivatives of Distamycin A

Pier Giovanni Baraldi, Romeo Romagnoli, Italo Beria, +6

Journal of Medicinal Chemistry

Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and Congeners

Italo Beria, Pier Giovanni Baraldi, Paolo Cozzi, +5

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryDerivativesChemoprevention Strategy +13

Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies

Pier Giovanni Baraldi, Italo Beria, Paolo Cozzi, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMustard DerivativesNatural SciencesMedicineOrganic Chemistry +7

Cytotoxic halogenoacrylic derivatives of distamycin A

Paolo Cozzi, Italo Beria, Marina Caldarelli, +3

Bioorganic & Medicinal Chemistry Letters

MedicineDistamycin APharmacologyDerivative (Chemistry)Drug Discovery

4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors

Italo Beria, Barbara Valsasina, Maria Gabriella Brasca, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +6

Cytotoxic α-bromoacrylic derivatives of distamycin analogues modified at the amidino moiety

Paolo Cozzi, Italo Beria, Marina Caldarelli, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryDerivativesBiochemistry +11