Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

Paola Magnaghi, Roberto D’Alessio, Barbara Valsasina, +21

Nature Chemical Biology

BiochemistryMedicineNatural SciencesApoptosisCell Death +8

Thiol-peptide level and proteomic changes in response to cadmium toxicity in Oryza sativa L. roots

Roberta Aina, Massimo Labra, Pietro Fumagalli, +6

Environmental and Experimental Botany

EngineeringBiochemistryThiol-peptide LevelL. RootsMedicine +10

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

Riccardo Colombo, Marina Caldarelli, Milena Mennecozzi, +16

Cancer Research

Cancer TherapyMitotic CheckpointMps1 KinaseMedicineMolecular Biology +12

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Elena Campaner, Alessandra Rustighi, Alessandro Zannini, +21

Nature Communications

NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

Barbara Valsasina, Italo Beria, Cristina Alli, +21

Molecular Cancer Therapeutics

Bipolar Spindle FormationAntitumor ActivityCell DeathCell CycleTumor Biology +15

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma

Renata Sano, Kateryna Krytska, Colleen Larmour, +10

Science Translational Medicine

Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo.

Ulisse Cucchi, Laura Gianellini, Anna De Ponti, +11

PubMed

Molecular RegulationCell DeathPathologyCellular PhysiologyTumor Biology +19

Structural Insight into Maternal Embryonic Leucine Zipper Kinase (MELK) Conformation and Inhibition toward Structure-Based Drug Design

Giulia Canevari, Stefania Re Depaolini, Ulisse Cucchi, +6

Biochemistry

Drug TargetMolecular BiologyStructural InsightMelk InhibitorsTumor Biology +14

Targeting Integrin α _V β ₃ with Theranostic RGD‐Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario

Arianna Pina, Alberto Dal Corso, Michele Caruso, +11

ChemistrySelect

Protein extraction from grape tissues by two-dimensional electrophoresis

Milena Marsoni, Candida Vannini, Manuela Campa, +3

Julius Kühn-Institut

EngineeringBiochemistryPhenol-based Extraction MethodMedicineBioanalysis +13