Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

Paola Magnaghi, Roberto D’Alessio, Barbara Valsasina, +21

Nature Chemical Biology

BiochemistryMedicineNatural SciencesApoptosisCell Death +8

Entrectinib, a Pan–TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications

Elena Ardini, Maria Menichincheri, Patrizia Banfi, +25

Molecular Cancer Therapeutics

Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

Maria Menichincheri, Elena Ardini, Paola Magnaghi, +26

Journal of Medicinal Chemistry

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

Paola Magnaghi, Catherine Roberts, Stéphanie Lorain, +2

Nature Genetics

Transcriptional Co-repressorsTranscriptional RegulationGeneticsGene RegulationYeast +6

Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors

R Bossi, Maria Beatrice Saccardo, Elena Ardini, +10

Biochemistry

EngineeringMolecular BiologyAnaplastic Lymphoma KinaseTumor BiologySignaling Pathway +16

The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition

Elena Ardini, Roberta Bosotti, Andrea Borgia, +25

Molecular Oncology

Trka Kinase InhibitionPathologyCancer BiologyTumor BiologyTumor Sensitivity +19

Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure–Activity Relationships

Paolo Polucci, Paola Magnaghi, Mauro Angiolini, +23

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryDrug TargetBiochemistryMedicine +13

Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury

Paola Magnaghi, Barbara Salom, Liviana Cozzi, +15

Molecular Cancer Therapeutics

Ten allelic apolipoprotein[a] 5' flanking fragments exhibit comparable promoter activities in HepG2 cells.

Selina Bopp, Silvano Köchl, Francesco Acquati, +6

Journal of Lipid Research

Characterization by yeast artificial chromosome cloning of the linked apolipoprotein(a) and plasminogen genes and identification of the apolipoprotein(a) 5' flanking region.

Nicoletta Malgaretti, Francesco Acquati, Paola Magnaghi, +6

Proceedings of the National Academy of Sciences

Plasminogen GenesPlasminogen FamilyAllelic VariantFlanking RegionMedicine +12