Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey, +24

Science Translational Medicine

PTEN-deficient cancers depend on PIK3CB

Susan Wee, Dmitri Wiederschain, Sauveur-Michel Maira, +6

Proceedings of the National Academy of Sciences

Tumor BiologyClass Ia Pi3kSignal TransductionSignaling PathwayCell Regulation +13

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, +7

Cell Reports

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition

Anthony C. Faber, Danan Li, Young-Chul Song, +9

Proceedings of the National Academy of Sciences

ApoptosisCell DeathTumor BiologyOncologyReceptor Tyrosine Kinase +14

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Julián Carretero, Takeshi Shimamura, Klarisa Rikova, +23

Cancer Cell

MedicineIntegrative GenomicCancer GenomicsBronchial NeoplasmRadiation Oncology +4

Antitumor Activity of NVP-BKM120—A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells

Dimpy Koul, Jun Fu, Ruijun Shen, +10

Clinical Cancer Research

Multi-Level Targeting of the Phosphatidylinositol-3-Kinase Pathway in Non-Small Cell Lung Cancer Cells

Christopher R. Zito, Lucia B. Jilaveanu, Valsamo Anagnostou, +7

PLoS ONE

A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition

Hailing Cheng, Pixu Liu, Fan Zhang, +11

Cancer Research

Tumor BiologyDual Pi3k/mtor InhibitorSignaling PathwayEndocrine-related CancerMedicine +13

Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α

Kira Gritsman, Haluk Yuzugullu, Thanh Von, +11

Journal of Clinical Investigation

Pi3k Isoform P110αPathologyCell DeathCancer BiologyDownstream Pi3k +18

High metastatic efficiency of human sarcoma cells in Rag2/γc double knockout mice provides a powerful test system for antimetastatic targeted therapy

Patrizia Nanni, Giordano Nicoletti, Lorena Landuzzi, +12

European Journal of Cancer

MedicineImmunologyTumor ImmunityHigh Metastatic EfficiencyImmunoediting +7