PTEN-deficient cancers depend on PIK3CB

Susan Wee, Dmitri Wiederschain, Sauveur-Michel Maira, +6

Proceedings of the National Academy of Sciences

Tumor BiologyClass Ia Pi3kSignal TransductionSignaling PathwayCell Regulation +13

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

Susan Wee, Zainab Jagani, Kay X. Xiang, +6

Cancer Research

BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases

Rory Geyer, Susan Wee, Scott Anderson, +2

Molecular Cell

Protein FunctionMolecular RegulationCullin 3Molecular BiologyProtein Degradation +5

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

Saskia M. Brachmann, Irmgard Hofmann, Christian Schnell, +6

Proceedings of the National Academy of Sciences

Dual Pi3k/mtor InhibitorBreast OncologyOncologyApoptosis InductionMedicine +13

CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability

Susan Wee, Rory Geyer, Takashi Toda, +1

Nature Cell Biology

Protein FunctionMolecular RegulationMolecular BiologyBiomolecular InteractionAutocatalytic Adapter Instability +1

Fission Yeast COP9/Signalosome Suppresses Cullin Activity through Recruitment of the Deubiquitylating Enzyme Ubp12p

Chunshui Zhou, Susan Wee, Edward K. Rhee, +3

Molecular Cell

Signal TransductionDeubiquitylating Enzyme Ubp12pMolecular RegulationNatural SciencesMolecular Biology +6

PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes

Chunshui Zhou, Fatih Arslan, Susan Wee, +5

BMC Biology

F-Box-Directed CRL Complex Assembly and Regulation by the CSN and CAND1

Michael Schmidt, Philip R. McQuary, Susan Wee, +2

Molecular Cell

EngineeringMolecular BiologyMulti-protein AssemblyCrystallographyStructural Biology +1

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of <i>ASCL1</i> Gene Expression

Ryan Lenhart, Stefan Kirov, Heshani Desilva, +10

Molecular Cancer Therapeutics

Cancer BiologyTumor BiologyTranscriptional RegulationCancer Cell BiologyBet Inhibition Is +14

Conservation of the COP9/signalosome in budding yeast.

Susan Wee, Bettina K. J. Hetfeld, Wolfgang Dubiel, +1

BMC Genetics

Natural SciencesYeastMolecular GeneticsCellular BiochemistryGene Expression +3