Betty Chan

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman et al. · Nature Medicine · 2018 · 491 citations · Full text

Tumor Biology, Medicine, Rna Splicing +9

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal et al. · Cell Reports · 2015 · 453 citations · Full text

Genetics, Rna Splicing, Molecular Biology +17

Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding

Kevin McCloskey, Eric A. Sigel, Steven Kearnes et al. · Journal of Medicinal Chemistry · 2020 · 157 citations · Full text

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Teng Teng, Jennifer Tsai, Xiaoling Puyang et al. · Nature Communications · 2017 · 147 citations · Full text

Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity<i>in vitro</i>and<i>in vivo</i>

Betty Chan, Garrett Greenan, Frank McKeon et al. · Proceedings of the National Academy of Sciences · 2005 · 109 citations · Full text