H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman, +33

Nature Medicine

Tumor BiologyMedicineRna SplicingInduces LethalityCell Biology +7

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal, +33

Cell Reports

GeneticsRna SplicingMolecular BiologyMolecular GeneticsCancer Biology +15

Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding

Kevin McCloskey, Eric A. Sigel, Steven Kearnes, +16

Journal of Medicinal Chemistry

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Teng Teng, Jennifer Tsai, Xiaoling Puyang, +27

Nature Communications

Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity<i>in vitro</i>and<i>in vivo</i>

Betty Chan, Garrett Greenan, Frank McKeon, +1

Proceedings of the National Academy of Sciences

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Lorenzo I. Finci, Xiaofeng Zhang, Xiuliang Huang, +14

Genes & Development

Plastic biochannel hybridization devices: a new concept for microfluidic DNA arrays

Ralf Lenigk, Robin H. Liu, M. M. Athavale, +10

Analytical Biochemistry

EngineeringBiosensing SystemsBiomedical DiagnosticsBioelectronicsNew Concept +7

The use of glasgow coma scale in poisoning

Betty Chan, P. L. Gaudry, T Grattan-Smith, +1

Journal of Emergency Medicine

Patient SafetyPoisoningBrain InjuryGlasgow Coma ScaleClinical Toxicology

Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening

Jeremy S. Disch, Jennifer M. Duffy, Esther C. Y. Lee, +23

Journal of Medicinal Chemistry

Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells

Donglin Guo, Albert Gao, David A. Michels, +9

Biotechnology and Bioengineering

OocyteMtx ConcentrationCytogeneticsGeneticsImmunology +19