Brian M. Beyer

Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

S. Shane Taremi, Brian M. Beyer, Nanhua Yao et al. · Protein Science · 1998 · 118 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Andrew Prongay, Zhuyan Guo, Nanhua Yao et al. · Journal of Medicinal Chemistry · 2007 · 108 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

Yu‐Sen Wang, Corey Strickland, Johannes Voigt et al. · Journal of Medicinal Chemistry · 2009 · 101 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease

Rumin Zhang, Brian M. Beyer, James Durkin et al. · Analytical Biochemistry · 1999 · 91 citations

Life Sciences, Biochemistry, Molecular Biology +8

IK682, a tight binding inhibitor of TACE

Xiaoda Niu, Shelby P. Umland, Richard Ingram et al. · Archives of Biochemistry and Biophysics · 2006 · 57 citations

Life Sciences, Medicinal Chemistry, Pharmacology +11