Structure of the hepatitis C virus RNA helicase domain

Nanhua Yao, Thomas Hesson, Michael Cable, +4

Nature Structural Biology

Virus StructureViral ReplicationRna Structure PredictionMolecular BiologyHepatitis +3

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase

Nanhua Yao, Paul Reichert, S. Shane Taremi, +2

Structure

Virus StructureCrystal StructureViral ReplicationViral Polymerase StructureProtein Assembly +10

A Novel Mechanism to Ensure Terminal Initiation by Hepatitis C Virus NS5B Polymerase

Zhi Hong, Craig E. Cameron, Michelle Walker, +4

Virology

Novel MechanismViral ReplicationMolecular VirologyHepatitis CViral Hepatitis +9

Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

I. Wayne Cheney, Shunqi Yan, T.C. Appleby, +6

Bioorganic & Medicinal Chemistry Letters

Substituted PyridonesMolecular PharmacologyMedicinal ChemistryPim-1 KinaseBiochemistry +13

Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super‐families of helicases

Sergey Korolev, Timothy M. Lohman, Gabriel Waksman, +2

Protein Science

Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

S. Shane Taremi, Brian M. Beyer, M. Maher, +4

Protein Science

Viral ReplicationEssential JunctionsMolecular VirologyBiochemistryHepatitis C Virus +13

Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

Martha De la Rosa, Hong Woo Kim, Esmir Gunić, +15

Bioorganic & Medicinal Chemistry Letters

Tri-substituted TriazolesMedicineHiv-1 Reverse TranscriptaseAntiviral Drug DevelopmentAntiviral Therapy +6

Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Andrew Prongay, Zhuyan Guo, Nanhua Yao, +28

Journal of Medicinal Chemistry

Protein AssemblyMolecular BiologyStructure-based OptimizationChemical BiologyPharmaceutical Chemistry +20

Refined 1.89-.ANG. Structure of the Histidine-Binding Protein Complexed with Histidine and Its Relationship with Many Other Active Transport/Chemosensory Proteins

Nanhua Yao, S. Trakhanov, Florante A. Quiocho

Biochemistry

Serine Protease of Hepatitis C Virus Expressed in Insect Cells as the NS3/4A Complex

D. Šali, Richard Ingram, Michele Wendel, +13

Biochemistry

Viral ReplicationHepatitis C VirusSynthetic VirologyImmunologyMolecular Biology +15