Structure of the hepatitis C virus RNA helicase domain

Nanhua Yao, Thomas Hesson, Michael Cable, +4

Nature Structural Biology

Virus StructureViral ReplicationRna Structure PredictionMolecular BiologyHepatitis +3

Detection and isolation of inactive, large molecular weight renin in human kidney and plasma.

Steven A. Atlas, Jean E. Sealey, B Dharmgrongartama, +2

Hypertension

Renal PathologyRenal InflammationProtein PurificationRenal FunctionBioanalysis +19

Immunological evidence that inactive renin is prorenin

Steven A. Atlas, P Christofalo, Thomas Hesson, +2

Biochemical and Biophysical Research Communications

Inactive ReninAdrenal GlandMedicineImmunologyAdrenal Disease +1

Characterization of inactive renin ("prorenin") from renin-secreting tumors of nonrenal origin. Similarity to inactive renin from kidney and normal plasma.

Steven A. Atlas, Thomas Hesson, Jean E. Sealey, +4

Journal of Clinical Investigation

Inactive ReninHypertensionUrologyRenin-secreting TumorsActive Renin +12

An Inactive, Prorenin-like Substance in Human Kidney and Plasma

Steven A. Atlas, John H. Laragh, Jean E. Sealey, +1

Clinical Science

Renal PathologyRenal InflammationAdrenal GlandRenal FunctionBioanalysis +16

Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors

Martin Himmelbauer, Zhili Xin, J. Howard Jones, +11

Journal of Medicinal Chemistry

Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

Tamara Halkina, Jaclyn L. Henderson, Edward Yin-Shiang Lin, +23

Journal of Medicinal Chemistry

Biochemical similarity of partially purified inactive renins from human plasma and kidney.

Steven A. Atlas, Jean E. Sealey, Thomas Hesson, +4

Hypertension

Active ReninRenal PathologyGlycobiologyRenal InflammationProtein Purification +18

Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

D.J. Marcotte, Mia Rushe, Robert M. Arduini, +15

Protein Science

Crystal StructureMolecular BiologyGerminal-center Kinase-like KinaseSignaling PathwayCell Regulation +15

Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors

Zhili Xin, Martin Himmelbauer, J. Howard Jones, +8

ACS Medicinal Chemistry Letters