Richard Ingram

Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

Peter Orth, Li Xiao, Lorraine D. Hernandez et al. · Journal of Biological Chemistry · 2014 · 135 citations · Full text

X-ray Crystallography, Microbial Pathogens, Immunology +22

Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Andrew Prongay, Zhuyan Guo, Nanhua Yao et al. · Journal of Medicinal Chemistry · 2007 · 106 citations · Full text

Protein Assembly, Molecular Biology, Structure-based Optimization +22

A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease

Rumin Zhang, Brian M. Beyer, James Durkin et al. · Analytical Biochemistry · 1999 · 91 citations

Diagnostic Virology, Biochemistry, Viral Diagnostics +9

Crystal Structure of the Catalytic Domain of Human ADAM33

Peter Orth, Paul Reichert, Wenyan Wang et al. · Journal of Molecular Biology · 2003 · 90 citations

Crystal Structure, Protein X-ray Crystallography, Structure Elucidation +2

Serine Protease of Hepatitis C Virus Expressed in Insect Cells as the NS3/4A Complex

D. Šali, Richard Ingram, Michele Wendel et al. · Biochemistry · 1998 · 69 citations

Viral Replication, Hepatitis C Virus, Synthetic Virology +17