Li Xiao

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

Erick J. Morris, Sharda Jha, Clifford R. Restaino et al. · Cancer Discovery · 2013 · 673 citations · Full text

Pharmacotherapy, Tumor Biology, Drug Resistance +20

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Mark A. Huffman, Anna Fryszkowska, Oscar Alvizo et al. · Science · 2019 · 601 citations

Enzyme-catalyzed Reactions, Biomanufacturing, Biosynthesis +15

Selective small-molecule inhibition of an RNA structural element

John A. Howe, Hao Wang, Thierry Fischmann et al. · Nature · 2015 · 411 citations

Natural Sciences, Rna Structure Prediction, Selective Small-molecule Inhibition +3

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Jack D. Scott, Duane E. DeMong, Thomas J. Greshock et al. · Journal of Medicinal Chemistry · 2017 · 140 citations · Full text

Drug Target, Pharmacotherapy, Medicinal Chemistry +16

Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

Peter Orth, Li Xiao, Lorraine D. Hernandez et al. · Journal of Biological Chemistry · 2014 · 135 citations · Full text

X-ray Crystallography, Microbial Pathogens, Immunology +22