James Durkin

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 151 citations · Full text

Medicinal Chemistry, Drug Target, Active Bace1 Inhibitor +11

A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease

Rumin Zhang, Brian M. Beyer, James Durkin et al. · Analytical Biochemistry · 1999 · 91 citations

Diagnostic Virology, Biochemistry, Viral Diagnostics +9

Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10

William T. Windsor, Rosalinda Syto, Anthony Tsarbopoulos et al. · Biochemistry · 1993 · 90 citations

Laboratory Immunology, Immunology, Immune Regulation +20

Molecular Characterization of the Melanin-Concentrating Hormone/Receptor Complex: Identification of Critical Residues Involved in Binding and Activation

Douglas Macdonald, Nicholas Murgolo, Rumin Zhang et al. · Molecular Pharmacology · 2000 · 87 citations

Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides

Rumin Zhang, James Durkin, William T. Windsor et al. · Journal of Virology · 1997 · 85 citations · Full text

Protein Chemistry, Biochemistry, Protein Folding +15