Satoru Asahi

Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Hiroshi Yamazaki, Mami Nakamura, Tomoko Komatsu et al. · Protein Expression and Purification · 2002 · 232 citations

Aldo-keto Reductase, Biochemistry, Biochemical Genetics +7

Novel Inhibitor of p38 MAP Kinase as an Anti-TNF-α Drug:  Discovery of <i>N</i>-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent

Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani et al. · Journal of Medicinal Chemistry · 2005 · 145 citations · Full text

Novel Inhibitor, P38 Map Kinase, Immunology +23

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Tomohiro Kaku, Takenori Hitaka, Akio Ojida et al. · Bioorganic & Medicinal Chemistry · 2011 · 126 citations · Full text

Medicinal Chemistry, Selective 17,20-Lyase Inhibitor, Potential Utility +9

Establishment and Characterization of the Transformants Stably-Expressing MDR1 Derived from Various Animal Species in LLC-PK1

Toshiyuki Takeuchi, Sumie Yoshitomi, Tomoaki Higuchi et al. · Pharmaceutical Research · 2006 · 125 citations

Medicinal Chemistry, Molecular Characterization, Natural Sciences +6

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Masuo Yamaoka, Takahito Hara, Takenori Hitaka et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 116 citations

Steroid Synthesis, Medicinal Chemistry, Adrenal Gland +10