Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Hiroshi Yamazaki, Mami Nakamura, Tomoko Komatsu, +8

Protein Expression and Purification

Aldo-keto ReductaseBiochemistryBiochemical GeneticsEscherichia ColiMicrobiology +5

Novel Inhibitor of p38 MAP Kinase as an Anti-TNF-α Drug:  Discovery of <i>N</i>-[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent

Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani, +6

Journal of Medicinal Chemistry

Novel InhibitorP38 Map KinaseImmunologyCell DeathP38 Mitogen-activated Protein +21

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Tomohiro Kaku, Takenori Hitaka, Akio Ojida, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistrySelective 17,20-Lyase InhibitorPotential UtilityMedicinePharmacotherapy +7

Establishment and Characterization of the Transformants Stably-Expressing MDR1 Derived from Various Animal Species in LLC-PK1

Toshiyuki Takeuchi, Sumie Yoshitomi, Tomoaki Higuchi, +6

Pharmaceutical Research

Medicinal ChemistryMolecular CharacterizationNatural SciencesMolecular BiologyProtein Nmr +4

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Masuo Yamaoka, Takahito Hara, Takenori Hitaka, +7

The Journal of Steroid Biochemistry and Molecular Biology

Steroid SynthesisMedicinal ChemistryAdrenal GlandCynomolgus MonkeysEndocrine Mechanism +8

Kinetic Analyses for Species Differences in P-glycoprotein-Mediated Drug Transport

Miki Katoh, Naoto Suzuyama, Toshiyuki Takeuchi, +3

Journal of Pharmaceutical Sciences

BiochemistryMedicineGlycobiologySpecies DifferencesPharmacology +3

Enhancement of Cytochrome P-450 3A4 Catalytic Activities by Cytochrome b5 in Bacterial Membranes

Hiroshi Yamazaki, Miki Nakajima, Mami Nakamura, +6

Drug Metabolism and Disposition

Formation of A Dihydroxy Metabolite of Phenytoin in Human Liver Microsomes/cytosol: Roles of Cytochromes P450 2c9, 2c19, and 3a4

Tomoko Komatsu, Hiroshi Yamazaki, Satoru Asahi, +4

Drug Metabolism and Disposition

<i>In vitro</i> metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker

Hitomi Yamasaki, Naohiro Kawaguchi, Masami Nonaka, +5

Xenobiotica

A validated simultaneous quantification method for vonoprazan (TAK-438F) and its 4 metabolites in human plasma by the liquid chromatography-tandem mass spectrometry

Tomoki Yoneyama, Koichiro Teshima, Fumihiro Jinno, +2

Journal of Chromatography B

BiochemistryGas ChromatographyMedicineBioanalysisMass Spectrometry +9