Brandon Bravo

Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

Julie A. Di Paolo, Tao Huang, Mercedesz Balázs et al. · Nature Chemical Biology · 2010 · 332 citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +16

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Jacob R. Haling, Jawahar Sudhamsu, Ivana Yen et al. · Cancer Cell · 2014 · 253 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

Skye Montoya, Jessie Bourcier, Mark Noviski et al. · Science · 2024 · 148 citations · Full text

Medicine, Molecular Biology, Oncology +15

Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449)

Anthony M. Giannetti, Harvey Wong, Gerrit J.P. Dijkgraaf et al. · Journal of Medicinal Chemistry · 2011 · 75 citations · Full text

Medicine, Oncology, Pharmacology +17

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

Georgette M. Castanedo, Nicole Blaquière, Maureen H. Beresini et al. · Journal of Medicinal Chemistry · 2016 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17