Gerrit J.P. Dijkgraaf

Recurrent R-spondin fusions in colon cancer

Somasekar Seshagiri, Eric Stawiski, Steffen Durinck et al. · Nature · 2012 · 975 citations · Full text

Medicine, Genetics, Oncology +17

<i>Smoothened</i> Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch, Gerrit J.P. Dijkgraaf, Bruno Alicke et al. · Science · 2009 · 844 citations · Full text

Medicine, Cancer Biology, Oncology +17

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Felipe de Sousa e Melo, Antonina V. Kurtova, Jonathan M. Harnoss et al. · Nature · 2017 · 792 citations

Medicine, Cancer Biology, Oncology +16

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

Hayley J. Sharpe, Grégoire Pau, Gerrit J.P. Dijkgraaf et al. · Cancer Cell · 2015 · 389 citations · Full text

Medicine, Genetics, Molecular Genetics +15

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Gerrit J.P. Dijkgraaf, Bruno Alicke, Lasse Weinmann et al. · Cancer Research · 2010 · 363 citations · Full text

Medicine, Oncology, Pharmacology +13