Gerrit J.P. Dijkgraaf

Recurrent R-spondin fusions in colon cancer

Somasekar Seshagiri, Eric Stawiski, Steffen Durinck et al. · Nature · 2012 · 967 citations · Full text

<i>Smoothened</i> Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch, Gerrit J.P. Dijkgraaf, Bruno Alicke et al. · Science · 2009 · 837 citations · Full text

Health Sciences, Glioma, Genetics +14

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Felipe de Sousa e Melo, Antonina V. Kurtova, Jonathan M. Harnoss et al. · Nature · 2017 · 771 citations

Metastatic Colon Cancer, Distinct Role, Medicine +11

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

Hayley J. Sharpe, Grégoire Pau, Gerrit J.P. Dijkgraaf et al. · Cancer Cell · 2015 · 376 citations · Full text

Radiation Oncology, Oncology, Skin Cancer +12

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Gerrit J.P. Dijkgraaf, Bruno Alicke, Lasse Weinmann et al. · Cancer Research · 2010 · 363 citations · Full text

Molecular Biology, Glioma, Small Molecule Inhibition +18