Daohua Zhang

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 464 citations · Full text

Drug Target, Immunology, Cell Death +22

DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay et al. · Journal of Medicinal Chemistry · 2016 · 268 citations · Full text

Drug Target, Immunology, Kinase Inhibitors +17

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Philip A. Harris, Jill M. Marinis, John D. Lich et al. · ACS Medicinal Chemistry Letters · 2019 · 79 citations · Full text

Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity

Robert A. Stavenger, Haifeng Cui, Sarah E. Dowdell et al. · Journal of Medicinal Chemistry · 2006 · 71 citations · Full text

Drug Target, Bioorganic Chemistry, Pharmacotherapy +18

Aminomethylpiperazines as selective urotensin antagonists

Mark A. Hilfiker, Daohua Zhang, Sarah E. Dowdell et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 13 citations · Full text

Selective Urotensin Antagonists, Urology, Medicine +6