Tsutomu Nagata

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya et al. · Bioorganic & Medicinal Chemistry · 2008 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +6

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties

Kenji Yoshikawa, Shozo Kobayashi, Yumi Nakamoto et al. · Bioorganic & Medicinal Chemistry · 2009 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification

Satoshi Komoriya, Shozo Kobayashi, Ken Osanai et al. · Bioorganic & Medicinal Chemistry · 2005 · 42 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors

Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 33 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Bioorganic & Medicinal Chemistry · 2004 · 31 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12