Noriyasu Haginoya

Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-<i>c</i>]pyridine as S4 Binding Element

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Journal of Medicinal Chemistry · 2004 · 70 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, X-ray Crystal Analysis +18

Nucleosides and Nucleotides. 160. Synthesis of Oligodeoxyribonucleotides Containing 5-(<i>N</i>-Aminoalkyl)carbamoyl-2‘-deoxyuridines by a New Postsynthetic Modification Method and Their Thermal Stability and Nuclease-Resistance Properties

Noriyasu Haginoya, Akira Ono, Yukari Nomura et al. · Bioconjugate Chemistry · 1997 · 50 citations

Bioorganic Chemistry, Duplex Formation, Engineering +20

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model

Takeshi Jimbo, Mana Hatanaka, Takahiro Komatsu et al. · Oncotarget · 2019 · 47 citations · Full text

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya et al. · Bioorganic & Medicinal Chemistry · 2008 · 42 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties

Kenji Yoshikawa, Shozo Kobayashi, Yumi Nakamoto et al. · Bioorganic & Medicinal Chemistry · 2009 · 42 citations · Full text

Medicinal Chemistry, Natural Sciences, Drug Discovery +10