Toshiharu Yoshino - Concepedia

Author

Toshiharu Yoshino

Daiichi-Sankyo (Japan)

Also Known As

Toshiharu Yoshino

Publications

1.2K

Citations

H-Index

Concepts

All Affiliations

Daiichi-Sankyo (Japan)Sagami Chemical Research Institute Daiichi Sankyo (Germany)Daiichi University of Pharmacy Tokyo Institute of Technology

About

Toshiharu Yoshino is an author at Daiichi-Sankyo (Japan) specializing in natural sciences, organic chemistry, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	16	18	569
2	Medicine	14	16	482
3	Biochemistry	11	12	386
4	Engineering	10	10	385
5	Biomolecular Engineering	9	9	344

Toshiharu Yoshino

Publications

1.2K

Citations

H-Index

Page 1

	Year	Citations
Synthetic studies of huperzine A and its fluorinated analogues. 1. Novel asymmetric syntheses of an enantiomeric pair of huperzine A Satoru Kaneko, Toshiharu Yoshino, Tadashi Katoh, Tetrahedron Fluorous SynthesisOrganic ChemistryChemistryFluorinated AnaloguesPharmacology	1998	86
Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-<i>c</i>]pyridine as S4 Binding Element Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya, Journal of Medicinal Chemistry Pharmaceutical ScienceBioorganic ChemistryX-ray Crystal AnalysisPharmacotherapyHeterocycle Chemistry	2004	70
A Total Synthesis of Xestodecalactone A and Proof of Its Absolute Stereochemistry: Interesting Observations on Dienophilic Control with 1,3-Disubstituted Nonequivalent Allenes Toshiharu Yoshino, Fay Ng, Samuel J. Danishefsky Journal of the American Chemical Society	2006	60
Total synthesis of natural (+)-FR900482. 2. Efficient syntheses of the aromatic and the optically active aliphatic fragments Toshiharu Yoshino, Y. NAGATA, Etsuko Itoh, Tetrahedron Letters EngineeringAlkene MetathesisEfficient SynthesesTotal SynthesisOrganic Chemistry	1996	59
Total synthesis of an enantiomeric pair of FR900482. 1. Synthetic and end-game strategies Tadashi Katoh, Etsuko Itoh, Toshiharu Yoshino, Tetrahedron Enantiomeric PairEngineeringNatural SciencesDiversity-oriented SynthesisSynthetic Biology	1997	51
A novel enantioselective synthesis of the key intermediate of (−)-huperzine a employing asymmetric palladium-catalyzed bicycloannulation Satoru Kaneko, Toshiharu Yoshino, Tadashi Katoh, Tetrahedron Asymmetry Chemical EngineeringNovel Enantioselective SynthesisKey IntermediateEngineeringOrganic Chemistry	1997	50
Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments Toshiharu Yoshino, Y. NAGATA, Etsuko Itoh, Tetrahedron Enantiomeric PairEngineeringTotal SynthesisOrganic ChemistryActive Aliphatic Segments	1997	43
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya, Bioorganic & Medicinal Chemistry Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design	2008	42
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties Kenji Yoshikawa, Shozo Kobayashi, Yumi Nakamoto, Bioorganic & Medicinal Chemistry Medicinal ChemistryNatural SciencesDrug DiscoveryDiversity-oriented SynthesisMedicine	2009	42
Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification Satoshi Komoriya, Shozo Kobayashi, Ken Osanai, Bioorganic & Medicinal Chemistry Biological ActivityMedicinal ChemistryMetabolic StabilityBiochemistryNatural Sciences	2005	42

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