Syozo Kobayashi

Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-<i>c</i>]pyridine as S4 Binding Element

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Journal of Medicinal Chemistry · 2004 · 70 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, X-ray Crystal Analysis +18

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya et al. · Bioorganic & Medicinal Chemistry · 2008 · 42 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Bioorganic & Medicinal Chemistry · 2004 · 31 citations

Biological Activity, Medicinal Chemistry, Biochemistry +10

Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 19 citations · Full text

Medicinal Chemistry, Medicine, Pharmacological Agent +5