Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units

Intramolecular Nonbonded S···O Interaction Recognized in (Acylimino)thiadiazoline Derivatives as Angiotensin II Receptor Antagonists and Related Compounds

Yoshimitsu Nagao, Terukage Hirata, Satoru Goto et al. · Journal of the American Chemical Society · 1998 · 270 citations

Pharmacy, Chemistry, Medicinal Chemistry +17

Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors

S. Maignan, J.P. Guilloteau, Stéphanie Pouzieux et al. · Journal of Medicinal Chemistry · 2000 · 139 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors:  Preference for a Neutral Group in the S1 Pocket

S. Maignan, J.P. Guilloteau, Yong Mi Choi-Sledeski et al. · Journal of Medicinal Chemistry · 2003 · 119 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of 4-[(<i>Z</i>)-(4-Bromophenyl)- (ethoxyimino)methyl]-1‘-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4‘-methyl-1,4‘- bipiperidine <i>N</i>-Oxide (SCH 351125):  An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection

Anandan Palani, Sherry Shapiro, John W. Clader et al. · Journal of Medicinal Chemistry · 2001 · 95 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-<i>c</i>]pyridine as S4 Binding Element

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Journal of Medicinal Chemistry · 2004 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17