Satoshi Komoriya

Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors

Takayasu Nagahara, Yukio Yokoyama, Kazue Inamura et al. · Journal of Medicinal Chemistry · 1994 · 178 citations · Full text

Factor X, Medicinal Chemistry, Pharmaceutical Chemistry +15

Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-<i>c</i>]pyridine as S4 Binding Element

Noriyasu Haginoya, Syozo Kobayashi, Satoshi Komoriya et al. · Journal of Medicinal Chemistry · 2004 · 70 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, X-ray Crystal Analysis +18

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya et al. · Bioorganic & Medicinal Chemistry · 2008 · 42 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties

Kenji Yoshikawa, Shozo Kobayashi, Yumi Nakamoto et al. · Bioorganic & Medicinal Chemistry · 2009 · 42 citations · Full text

Medicinal Chemistry, Natural Sciences, Drug Discovery +10

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification

Satoshi Komoriya, Shozo Kobayashi, Ken Osanai et al. · Bioorganic & Medicinal Chemistry · 2005 · 42 citations

Biological Activity, Medicinal Chemistry, Metabolic Stability +9