John W. Clader

Discovery of 1-(4-Fluorophenyl)-(3<i>R</i>)-[3-(4-fluorophenyl)-(3<i>S</i>)- hydroxypropyl]-(4<i>S</i>)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):  A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Stuart B. Rosenblum, Tram Huynh, Adriano Afonso et al. · Journal of Medicinal Chemistry · 1998 · 352 citations

Serum Total Cholesterol, Pharmaceutical Science, Pharmacotherapy +18

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

Alexandra Trkola, Shawn E. Kuhmann, Julie Strizki et al. · Proceedings of the National Academy of Sciences · 2002 · 303 citations · Full text

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection<i>in vitro</i>and<i>in vivo</i>

Julie Strizki, Serena Xu, Nicole Wagner et al. · Proceedings of the National Academy of Sciences · 2001 · 300 citations · Full text

2-Azetidinones as Inhibitors of Cholesterol Absorption

Duane A. Burnett, Mary Ann Caplen, Harry R. Davis et al. · Journal of Medicinal Chemistry · 1994 · 238 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +15

Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry

Fotini Tsamis, Svetlana Gavrilov, Francis Kajumo et al. · Journal of Virology · 2003 · 204 citations · Full text

Ccr5 Function, Immunology, Molecular Biology +16