2-Azetidinones as Inhibitors of Cholesterol Absorption

Duane A. Burnett, Mary Ann Caplen, Harry R. Davis, +2

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryPharmaceutical ScienceBiochemistry +13

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption

S. Altmann, Harry R. Davis, Xiaorui Yao, +11

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Signal TransductionMedicineLiver PhysiologyPhysiologyImmunology +9

2-Azetidinone Cholesterol Absorption Inhibitors:  Structure−Activity Relationships on the Heterocyclic Nucleus

John W. Clader, Duane A. Burnett, Mary Ann Caplen, +8

Journal of Medicinal Chemistry

Medicinal ChemistryHeterocyclicPharmacological StudyBiochemistryOxysterol +12

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

Brian Salisbury, Harry R. Davis, Robert E. Burrier, +13

Atherosclerosis

OxysterolBiochemistryMedicineCholesterol AbsorptionSch 48461 +8

Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

Margaret Browne, Duane A. Burnett, Mary Ann Caplen, +8

Tetrahedron Letters

Enantioselective SynthesisOrganic ChemistryStereoselective SynthesisChemistryAcid Chloride-imine Reaction +3

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

Ho-Sam Ahn, Leyla Arik, George Boykow, +8

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineMechanism Of ActionPharmacological AgentThrombin Receptor Antagonists +3

Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors

Duane A. Burnett, Mary Ann Caplen, Martin S. Domalski, +3

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineIodinated Biochemical ToolsCholesterol Absorption InhibitorsDrug Development +5

Synthesis and structure–activity relationships of aminoalkylazetidines as ORL1 receptor ligands

Wen‐Lian Wu, Mary Ann Caplen, Martin S. Domalski, +3

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyOrl1 Receptor LigandsBiochemistryMedicineNatural Sciences +5

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Wen‐Lian Wu, Duane A. Burnett, Mary Ann Caplen, +9

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryPharmaceutical ScienceEfficacious BenzimidazolesBiochemistryMedicine +5

Identification of 2-aminooxazole amides as acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy

Hyunjin M. Kim, Michelle Smith, Jae‐Hun Kim, +6

Bioorganic & Medicinal Chemistry Letters

Scaffold Hopping StrategyCombinatorial ChemistryMedicinal ChemistryBiochemistryNatural Sciences +8