An orally available non-nucleotide STING agonist with antitumor activity

Bo‐Sheng Pan, Samanthi A. Perera, Jennifer Piesvaux, +38

Science

Antitumor ActivityImmunologyImmunoeditingImmunologic MechanismPharmacotherapy +17

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

Alexandra Trkola, Shawn E. Kuhmann, Julie Strizki, +14

Proceedings of the National Academy of Sciences

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection<i>in vitro</i>and<i>in vivo</i>

Julie Strizki, Serena Xu, Nicole Wagner, +22

Proceedings of the National Academy of Sciences

Preclinical Characterization of¹⁸F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Eric D. Hostetler, Abbas Walji, Zhizhen Zeng, +20

Journal of Nuclear Medicine

Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage

D. Cecilia, Vineet N. KewalRamani, Jeanne O’Leary, +6

Journal of Virology

Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1

Julie Strizki, Cécile Tremblay, Serena Xu, +15

Antimicrobial Agents and Chemotherapy

Antiviral CompoundNeurovirologyMedicineImmunologyAntiviral Response +13

Immune Responses to Human Immunodeficiency Virus (HIV) Type 1 Induced by Canarypox Expressing HIV‐1_Mngp120, HIV‐1_SF2Recombinant gp120, or Both Vaccines in Seronegative Adults

Mary Lou Clements‐Mann, Kent J. Weinhold, Thomas J. Matthews, +24

The Journal of Infectious Diseases

ImmunodeficienciesImmunologyImmunodominanceHiv-1sf2 Neutralizing AntibodiesHuman Immunodeficiency Virus +17

Discovery of 6-(Fluoro-¹⁸<i>F</i>)-3-(1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-1-yl)isoquinolin-5-amine ([¹⁸F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Abbas Walji, Eric D. Hostetler, Harold G. Selnick, +32

Journal of Medicinal Chemistry

EngineeringImaging AgentMagnetic ResonanceNeurochemical BiomarkersPositron Emission Tomography +20

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Tony Siu, Michael D. Altman, Gretchen A. Baltus, +12

ACS Medicinal Chemistry Letters

Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)

Andre J. Marozsan, Shawn E. Kuhmann, Thomas K Morgan, +6

Virology

Isolate ResistantMedicineHuman RetrovirusImmunologyAntiviral Drug Development +8