Abdellah Tahri

TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

Sandra De Meyer, Hilde Azijn, Dominique Surleraux et al. · Antimicrobial Agents and Chemotherapy · 2005 · 354 citations · Full text

Broad Range, Protease Inhibitor, Antiviral Activity +15

Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor

Dominique Surleraux, Abdellah Tahri, Wim G. Verschueren et al. · Journal of Medicinal Chemistry · 2004 · 255 citations

Immunology, Molecular Biology, Antiviral Drug +16

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 136 citations

Novel Series, Biochemistry, Structure–activity Relationship Study +7

Synthesis of α-carbolines and β-carbolinones via intramolecular Diels-Alder reactions of 2(1H)-pyrazinones

Abdellah Tahri, Kris J. Buysens, Erik V. Van der Eycken et al. · Tetrahedron · 1998 · 64 citations

Engineering, Organic Chemistry, Stereoselective Synthesis +6

Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase

Koen Vandyck, Maxwell D. Cummings, Origène Nyanguile et al. · Journal of Medicinal Chemistry · 2009 · 60 citations