Dennis J. Selkoe

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron, David Westaway, Weiming Xia et al. · Nature Medicine · 1997 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Jie Shen, Roderick T. Bronson, Dongfeng Chen et al. · Cell · 1997 · 957 citations · Full text

Life Sciences, Genetics, Neuroscience +10

Protein Topology of Presenilin 1

Andrew Doan, Gopal Thinakaran, David Borchelt et al. · Neuron · 1996 · 374 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein

Paul E. Fraser, Jack Nguyen, Hideyo Inouye et al. · Biochemistry · 1992 · 249 citations

Life Sciences, Biochemistry, Dementia +16

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

Jochen Walter, Anja Capell, Jürgen Grünberg et al. · Molecular Medicine · 1996 · 228 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13