Paul Fraser

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron, David Westaway, Weiming Xia et al. · Nature Medicine · 1997 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations

Agnès Petit-Paitel, Toshitaka Kawarai, Erwan Paitel et al. · Journal of Biological Chemistry · 2005 · 324 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt‐Ulms et al. · Nature · 2006 · 297 citations

Life Sciences, Cell Biology, Molecular Biology +7

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

Jochen Walter, Anja Capell, Jürgen Grünberg et al. · Molecular Medicine · 1996 · 228 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

Masaki Nishimura, Gang Yu, Georges Lévesque et al. · Nature Medicine · 1999 · 222 citations

Life Sciences, Molecular Biology, Neuroscience +13