Hiroshi Hasegawa

Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations

Agnès Petit-Paitel, Toshitaka Kawarai, Erwan Paitel et al. · Journal of Biological Chemistry · 2005 · 323 citations · Full text

Mitophagy, Parkinson Disease-related Mutations, Cell Death +17

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt‐Ulms et al. · Nature · 2006 · 296 citations

Protein Secretion, Signal Transduction, ɛ-Secretase Activity +9

APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes

Yongjun Gu, Fusheng Chen, Nobuo Sanjo et al. · Journal of Biological Chemistry · 2003 · 147 citations · Full text

Reactive Oxygen Species in Mechanical Stress-Induced Cardiac Hypertrophy

Ryuichi Aikawa, Toshio Nagai, Mariko Tanaka et al. · Biochemical and Biophysical Research Communications · 2001 · 131 citations

Mechanobiology, Cardiac Muscle, Cardiomyopathy +6

Presenilin 1 Mutations Activate γ42-Secretase but Reciprocally Inhibit ε-Secretase Cleavage of Amyloid Precursor Protein (APP) and S3-Cleavage of Notch

Fusheng Chen, Yongjun Gu, Hiroshi Hasegawa et al. · Journal of Biological Chemistry · 2002 · 107 citations · Full text