Sachiya Ikeda

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Dehua Chui, Hiroshi Tanahashi, Kazuharu Ozawa et al. · Nature Medicine · 1999 · 366 citations

Neurodegenerative Diseases, Alzheimer's Disease, Alzheimer Presenilin 1 +11

Discovery of Tofogliflozin, a Novel <i>C</i>-Arylglucoside with an <i>O</i>-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Yoshihito Ohtake, Tsutomu Sato, Takamitsu Kobayashi et al. · Journal of Medicinal Chemistry · 2012 · 165 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Molecular Pharmacology +16

Tofogliflozin, a Potent and Highly Specific Sodium/Glucose Cotransporter 2 Inhibitor, Improves Glycemic Control in Diabetic Rats and Mice

Masayuki Suzuki, Kiyofumi Honda, Masanori Fukazawa et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 164 citations

Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice

Atsushi Obata, Naoto Kubota, Tetsuya Kubota et al. · Endocrinology · 2015 · 144 citations · Full text

Nutrition, Metabolic Disorder, Caloric Restriction +23

Oxidized low density lipoprotein caused CNS neuron cell death

Makoto Sugawa, Sachiya Ikeda, Yoichi Kushima et al. · Brain Research · 1997 · 57 citations

Low Density Lipoprotein, Lipid Peroxidation, Cell Death +6