Sachiya Ikeda

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Dehua Chui, Hiroshi Tanahashi, Kazuharu Ozawa et al. · Nature Medicine · 1999 · 366 citations

Life Sciences, Neurology, Neuroscience +17

Discovery of Tofogliflozin, a Novel <i>C</i>-Arylglucoside with an <i>O</i>-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Yoshihito Ohtake, Tsutomu Sato, Takamitsu Kobayashi et al. · Journal of Medicinal Chemistry · 2012 · 168 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Tofogliflozin, a Potent and Highly Specific Sodium/Glucose Cotransporter 2 Inhibitor, Improves Glycemic Control in Diabetic Rats and Mice

Masayuki Suzuki, Kiyofumi Honda, Masanori Fukazawa et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 166 citations

Medicine, Pharmacology, Pharmacotherapy +17

Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice

Atsushi Obata, Naoto Kubota, Tetsuya Kubota et al. · Endocrinology · 2015 · 146 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Oxidized low density lipoprotein caused CNS neuron cell death

Makoto Sugawa, Sachiya Ikeda, Yoichi Kushima et al. · Brain Research · 1997 · 57 citations

Life Sciences, Neurobiology, Neuroscience +14