Yoshihito Ohtake

Discovery of Tofogliflozin, a Novel <i>C</i>-Arylglucoside with an <i>O</i>-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Yoshihito Ohtake, Tsutomu Sato, Takamitsu Kobayashi et al. · Journal of Medicinal Chemistry · 2012 · 165 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Molecular Pharmacology +16

Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]: A Notable Catalyst for Enantiotopically Selective Aromatic Substitution Reactions of α-Diazocarbonyl Compounds

Nobuhide Watanabe, Takanori Ogawa, Yoshihito Ohtake et al. · Synlett · 1996 · 111 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +15

Lewis Acid-Promoted Diastereoselective Radical Cyclization Using Chiral .alpha.,.beta.-Unsaturated Esters

Mayumi Nishida, Eiji Ueyama, Hiroshi Hayashi et al. · Journal of the American Chemical Society · 1994 · 65 citations

Engineering, Biochemistry, Donut Icon +12

Asymmetric creation of quaternary carbon centers by enantiotopically selective aromatic C-H insertion catalyzed by chiral dirhodium(II) car☐ylates

Nobuhide Watanabe, Yoshihito Ohtake, Shunichi Hashimoto et al. · Tetrahedron Letters · 1995 · 61 citations

Asymmetric Catalysis, Chemical Engineering, Cross-coupling Reaction +9

Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens

Yoshitake Kanbe, Myung-Hwa Kim, Masahiro Nishimoto et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 30 citations

Medicinal Chemistry, Derivative (Chemistry), Biochemistry +10