Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens

A potent specific pure antiestrogen with clinical potential.

A. E. Wakeling, Michael Dukes, Jean Bowler · PubMed · 1991 · 1.1K citations

Molecular Pharmacology, Medicinal Chemistry, Antiestrogenic Potency +13

Fulvestrant, Formerly ICI 182,780, Is as Effective as Anastrozole in Postmenopausal Women With Advanced Breast Cancer Progressing After Prior Endocrine Treatment

Anthony Howell, J.F.R. Robertson, J. Albano et al. · Journal of Clinical Oncology · 2002 · 668 citations

Double-Blind, Randomized Trial Comparing the Efficacy and Tolerability of Fulvestrant Versus Anastrozole in Postmenopausal Women With Advanced Breast Cancer Progressing on Prior Endocrine Therapy: Results of a North American Trial

C. Kent Osborne, John Pippen, Stephen E. Jones et al. · Journal of Clinical Oncology · 2002 · 643 citations

Structural Insights into the Mode of Action of a Pure Antiestrogen

A.C.W. Pike, A.M. Brzozowski, Julia Walton et al. · Structure · 2001 · 344 citations · Full text

Chemical Biology, Endocrine-related Cancer, Biochemistry +10

Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women

J.F.R. Robertson, C. Kent Osborne, Anthony Howell et al. · Cancer · 2003 · 312 citations · Full text