Michael Dukes

A potent specific pure antiestrogen with clinical potential.

A. E. Wakeling, Michael Dukes, Jean Bowler · PubMed · 1991 · 1.1K citations

Molecular Pharmacology, Medicinal Chemistry, Antiestrogenic Potency +13

ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

Stephen R. Wedge, Donald Ogilvie, Michael Dukes et al. · PubMed · 2002 · 802 citations

Oral Administration, Pharmacotherapy, Tumor Biology +18

AZD2171: A Highly Potent, Orally Bioavailable, Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for the Treatment of Cancer

Stephen R. Wedge, Jane Kendrew, Laurent Hennequin et al. · Cancer Research · 2005 · 706 citations · Full text

Novel 4-Anilinoquinazolines with C-7 Basic Side Chains:  Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Laurent Hennequin, Elaine S. E. Stokes, Andrew P. Thomas et al. · Journal of Medicinal Chemistry · 2002 · 308 citations · Full text

Combinatorial Chemistry, Tyrosine Kinase, Orally Active +16

Arimidex�: A potent and selective fourth-generation aromatase inhibitor

Paul V. Plourde, Martin C. Dyroff, Michael Dukes · Breast Cancer Research and Treatment · 1994 · 257 citations

Medicine, Aromatase, Pharmacotherapy +5