A.C.W. Pike

Molecular basis of agonism and antagonism in the oestrogen receptor

A.M. Brzozowski, A.C.W. Pike, Zbigniew Dauter et al. · Nature · 1997 · 3.3K citations

Life Sciences, Endocrinology, Pharmacology +14

Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

A.C.W. Pike · The EMBO Journal · 1999 · 971 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Structural Insights into the Mode of Action of a Pure Antiestrogen

A.C.W. Pike, A.M. Brzozowski, Julia Walton et al. · Structure · 2001 · 345 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +8

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Yin Yao Dong, A.C.W. Pike, Alexandra Mackenzie et al. · Science · 2015 · 312 citations · Full text

Medicine, Molecular Biology, Pharmacology +17

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

P. Rellos, A.C.W. Pike, F. Niesen et al. · PLoS Biology · 2010 · 306 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17