Hideo Toyoshima

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

Hideo Toyoshima, Tony Hunter · Cell · 1994 · 2.1K citations

Novel Inhibitor, Signal Transduction, Cell Regulation +6

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi et al. · Nature Medicine · 2007 · 535 citations

Obesity, Metabolic Syndrome, Biochemistry +10

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi et al. · Nature Cell Biology · 2004 · 315 citations

Metabolic Syndrome, Signal Transduction, Hepatology +8

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Yoshimi Nakagawa, Hitoshi Shimano, Tomohiro Yoshikawa et al. · Nature Medicine · 2005 · 207 citations

Metabolic Syndrome, Transcriptional Regulation, Systems Biology +13

Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi et al. · Diabetes · 2004 · 189 citations · Full text

Streptozotocin-treated Mice, Insulin Signaling, Stz-administered Mice +21