Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, +23

Nature Medicine

ObesityMetabolic SyndromeBiochemistryDiabetesPhysiology +8

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

Tomohiro Yoshikawa, Hitoshi Shimano, Michiyo Amemiya-Kudo, +13

Molecular and Cellular Biology

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

Tomohiro Yoshikawa, Hitoshi Shimano, Naoya Yahagi, +15

Journal of Biological Chemistry

Promoter ActivityPufa SuppressionFatty Liver DiseaseLiver X ReceptorFatty Acids +14

Polyunsaturated Fatty Acids Ameliorate Hepatic Steatosis in Obese Mice by Srebp–1 Suppression

Motohiro Sekiya, Naoya Yahagi, Takashi Matsuzaka, +7

Hepatology

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Michiyo Amemiya-Kudo, Hitoshi Shimano, Alyssa H. Hasty, +14

Journal of Lipid Research

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice

Naoya Yahagi, Hitoshi Shimano, Alyssa H. Hasty, +15

Journal of Biological Chemistry

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

Yumiko Oishi, Nathanael J. Spann, Verena M. Link, +14

Cell Metabolism

InflammationSignal TransductionImmunologyPro-inflammatory Tlr4 SignalingChronic Inflammation +7

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi, +10

Nature Cell Biology

Metabolic SyndromeSignal TransductionHepatologyBiochemistryLiver Physiology +6

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, +12

Journal of Lipid Research

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

Naoya Yahagi, Hitoshi Shimano, Kiyoshi Hasegawa, +16

European Journal of Cancer

HepatologyBiochemistryNatural SciencesLiver PhysiologyLiver Cancer +5