Hitoshi Shimano

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Hitoshi Shimano, Jay D. Horton, Iichiro Shimomura et al. · Journal of Clinical Investigation · 1997 · 834 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Hitoshi Shimano, Jay D. Horton, Robert E. Hammer et al. · Journal of Clinical Investigation · 1996 · 818 citations · Full text

Life Sciences, Cell Biology, Molecular Genetics +15

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Iichiro Shimomura, Hitoshi Shimano, Jay D. Horton et al. · Journal of Clinical Investigation · 1997 · 754 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +11

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Jay D. Horton, Iichiro Shimomura, Matthew Brown et al. · Journal of Clinical Investigation · 1998 · 707 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo et al. · Journal of Biological Chemistry · 1999 · 687 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17