Hitoshi Shimano

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Hitoshi Shimano, Jay D. Horton, Iichiro Shimomura et al. · Journal of Clinical Investigation · 1997 · 831 citations · Full text

Fatty Liver Disease, Transgenic Mice, Transcriptional Regulation +19

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Hitoshi Shimano, Jay D. Horton, Robert E. Hammer et al. · Journal of Clinical Investigation · 1996 · 815 citations · Full text

Fatty Liver Disease, Transgenic Mice, Cellular Physiology +22

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Iichiro Shimomura, Hitoshi Shimano, Jay D. Horton et al. · Journal of Clinical Investigation · 1997 · 754 citations · Full text

Exons 1A, Molecular Regulation, Insulin Signaling +18

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Jay D. Horton, Iichiro Shimomura, Matthew Brown et al. · Journal of Clinical Investigation · 1998 · 704 citations · Full text

Metabolic Syndrome, Cholesterol Biosynthesis, Biochemistry +15

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo et al. · Journal of Biological Chemistry · 1999 · 682 citations · Full text