Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, +26

Nature Medicine

Metabolic SyndromeSystems BiologySignal TransductionBiochemistryMetabolic Actions +6

Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

Nozomu Kamei, Kazuyuki Tobe, Ryo Suzuki, +21

Journal of Biological Chemistry

The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

Toshimasa Yamauchi, Junji Kamon, Hironori Waki, +13

Journal of Biological Chemistry

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

Tetsuya Kubota, Naoto Kubota, Hiroki Kumagai, +35

Cell Metabolism

Metabolic SyndromeMolecular PhysiologyImpaired Insulin SignalingEndothelial CellsSkeletal Muscle +11

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

Tomohiro Yoshikawa, Hitoshi Shimano, Naoya Yahagi, +15

Journal of Biological Chemistry

Promoter ActivityPufa SuppressionFatty Liver DiseaseLiver X ReceptorFatty Acids +14

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice

Naoya Yahagi, Hitoshi Shimano, Alyssa H. Hasty, +15

Journal of Biological Chemistry

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi, +10

Nature Cell Biology

Metabolic SyndromeSignal TransductionHepatologyBiochemistryLiver Physiology +6

Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

Toshimasa Yamauchi, Hironori Waki, Junji Kamon, +22

Journal of Clinical Investigation

p53 Activation in Adipocytes of Obese Mice

Naoya Yahagi, Hitoshi Shimano, Takashi Matsuzaka, +15

Journal of Biological Chemistry

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Yoshimi Nakagawa, Hitoshi Shimano, Tomohiro Yoshikawa, +13

Nature Medicine

Metabolic SyndromeTranscriptional RegulationSystems BiologySignal TransductionSignaling Pathway +11