Jianyong Chen

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern et al. · Proceedings of the National Academy of Sciences · 2008 · 650 citations · Full text

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(−)-gossypol] against diffuse large cell lymphoma

Ramzi M. Mohammad, Shaomeng Wang, Amro Aboukameel et al. · Molecular Cancer Therapeutics · 2005 · 141 citations · Full text

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

Jianyong Chen, Longchuan Bai, Denzil Bernard et al. · ACS Medicinal Chemistry Letters · 2010 · 98 citations

Drug Target, Drug Targeting, Medicine +15

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

Alan A Arnold, Amro Aboukameel, Jianyong Chen et al. · Molecular Cancer · 2008 · 82 citations · Full text

Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein

Jianyong Chen, Zaneta Nikolovska‐Coleska, Guoping Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 72 citations · Full text

Medicinal Chemistry, New Embelin Derivatives, Drug Discovery +9