Denzil Bernard

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern et al. · Proceedings of the National Academy of Sciences · 2008 · 650 citations · Full text

SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression

Shaomeng Wang, Wei Sun, Yujun Zhao et al. · Cancer Research · 2014 · 335 citations · Full text

A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

Yujun Zhao, Shanghai Yu, Wei Sun et al. · Journal of Medicinal Chemistry · 2013 · 294 citations · Full text

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

Yujun Zhao, Liu Liu, Wei Sun et al. · Journal of the American Chemical Society · 2013 · 228 citations · Full text

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

Hacer Karataş, Elizabeth C. Townsend, Fang Cao et al. · Journal of the American Chemical Society · 2012 · 210 citations · Full text

Mll1/wdr5 Protein–protein Interaction, Drug Target, Mixed Lineage +18