Jonathan O′Shea

Multivalent <i>N</i>-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan et al. · Journal of the American Chemical Society · 2014 · 1.1K citations

Pharmacy, Pharmaceutics, Pharmacology +17

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

Molly Plovanich, Roman L. Bogorad, Yasemin Sancak et al. · PLoS ONE · 2013 · 463 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent <i>N</i>‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo

Kallanthottathil G. Rajeev, Jayaprakash K. Nair, Muthusamy Jayaraman et al. · ChemBioChem · 2015 · 184 citations

Pharmacy, Biotechnology, Molecular Biology +17

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides

Alexander V. Kel’in, Ivan Zlatev, Joel M. Harp et al. · The Journal of Organic Chemistry · 2016 · 43 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo

Donald J. Foster, Scott Barros, Rick Duncan et al. · RNA · 2012 · 41 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +12