Candice L. Horn

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn et al. · Nature · 2007 · 1.3K citations

Medicine, Molecular Biology, Oncology +12

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Sonya Zabludoff, Chun Deng, Michael Grondine et al. · Molecular Cancer Therapeutics · 2008 · 410 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.

Michael Zinda, Mac Johnson, Joshua Paul et al. · PubMed · 2001 · 150 citations

Medicine, Molecular Biology, Oncology +15

Discovery of Checkpoint Kinase Inhibitor (<i>S</i>)-5-(3-Fluorophenyl)-<i>N</i>-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas

Vibha Oza, Susan Ashwell, Lynsie Almeida et al. · Journal of Medicinal Chemistry · 2012 · 70 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms

Timothy I. Meier, James A. Cook, James E. Thomas et al. · Protein Expression and Purification · 2004 · 46 citations

Life Sciences, Biochemistry, Molecular Biology +11