Sonya Zabludoff

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Andrew L. Kung, Sonya Zabludoff, Dennis S. France et al. · Cancer Cell · 2004 · 474 citations · Full text

Transcriptional Coactivation, Transcriptional Regulation, Redox Regulator +9

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Sonya Zabludoff, Chun Deng, Michael Grondine et al. · Molecular Cancer Therapeutics · 2008 · 407 citations · Full text

Cell Death, Cell Cycle, Cancer Biology +17

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

Lidia Sambucetti, Denise Fischer, Sonya Zabludoff et al. · Journal of Biological Chemistry · 1999 · 392 citations · Full text

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair

Meredith A. Morgan, Leslie A. Parsels, Lili Zhao et al. · Cancer Research · 2010 · 296 citations · Full text

Dna Damage, Median Time, Molecular Biology +17

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

Edward A. Sausville, Patricia LoRusso, Michael A. Carducci et al. · Cancer Chemotherapy and Pharmacology · 2014 · 195 citations · Full text

Checkpoint Kinase Inhibitor, Medicine, Pathology +7