Luzi Jakob Barandun

Organocatalytic removal of formaldehyde adducts from RNA and DNA bases

Saswata Karmakar, Emily M. Harcourt, David S. Hewings et al. · Nature Chemistry · 2015 · 51 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +14

Inhibitors of the kinase IspE: structure–activity relationships and co-crystal structure analysis

Anna K. H. Hirsch, M.S. Alphey, Susan Lauw et al. · Organic & Biomolecular Chemistry · 2008 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Soaking suggests “alternative facts”: Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition

F.R. Ehrmann, Johann Stojko, A. Metz et al. · PLoS ONE · 2017 · 40 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and p<i>K</i>_aCalculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme

M. Neeb, Paul Czodrowski, A. Heine et al. · Journal of Medicinal Chemistry · 2014 · 32 citations

Life Sciences, Biochemistry, Chemistry +17

Launching Spiking Ligands into a Protein–Protein Interface: A Promising Strategy To Destabilize and Break Interface Formation in a tRNA Modifying Enzyme

F. Immekus, Luzi Jakob Barandun, Michael Betz et al. · ACS Chemical Biology · 2013 · 29 citations

Life Sciences, Biochemistry, Molecular Biology +17