A. Heine - Concepedia

Author

A. Heine

Philipps University of Marburg ORCID

Also Known As

A. HEINE, A. Heine, Andreas Heine, Andreas Heine,, C. Siefker, G. Klebe, G.M.A. Lima, Heine, A., Heine, Andreas

493

Publications

7.3K

Citations

H-Index

Concepts

All Affiliations

Philipps University of Marburg Scripps Research Institute ETH Zurich University at Buffalo, State University of New York University of Göttingen

About

A. Heine is an author at Philipps University of Marburg specializing in biochemistry, natural sciences, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	36	65	3.9K
2	Biochemistry	36	64	3.9K
3	Medicine	30	50	2.9K
4	Engineering	17	22	994
5	Biomolecular Engineering	7	7	212

A. Heine

126

Publications

6.9K

Citations

H-Index

Page 1

	Year	Citations
Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib: New Pharmacological Opportunities Due to Related Binding Site Recognition Alexander Weber, Angela Casini, A. Heine, Journal of Medicinal Chemistry Crystal StructureDrug TargetChemoprevention StrategyChemical BiologyCox-2 Selective Nsaids	2003	448
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope Carlos F. Barbas, A. Heine, Guofu Zhong, Science	1997	401
Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution A. Heine, Grace DeSantis, J.G. Luz, Science Transition StatesEnzyme MechanismAtomic ResolutionCellular EnzymologyBiochemistry	2001	279
Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes J. Schiebel, Roberto Gaspari, Tobias Wulsdorf, Nature Communications	2018	242
Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste Karen Köhler, Alexander Hillebrecht, Johannes Schulze Wischeler, Angewandte Chemie International Edition Food ChemistrySaccharin ConsumptionBioorganic ChemistryBiochemistryNatural Sciences	2007	178
Non-additivity of Functional Group Contributions in Protein–Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry Bernhard Baum, Laveena Muley, Michael Smolinski, Journal of Molecular Biology Protein ChemistryEngineeringBiochemistryProtein FoldingNatural Sciences	2010	160
Dissecting the Hydrophobic Effect on the Molecular Level: The Role of Water, Enthalpy, and Entropy in Ligand Binding to Thermolysin Nader N. Nasief, Michael Betz, A. Heine, Angewandte Chemie International Edition Protein ChemistryProteinlipid InteractionProtein AssemblyBiochemistryProtein Folding	2013	145
An Antibody exo Diels-Alderase Inhibitor Complex at 1.95 Angstrom Resolution A. Heine, E.A. Stura, Jari Yli‐Kauhaluoma, Science	1998	134
More than a Simple Lipophilic Contact: A Detailed Thermodynamic Analysis of Nonbasic Residues in the S1 Pocket of Thrombin Bernhard Baum, Menshawy Mohamed, Mohamed F. Zayed, Journal of Molecular Biology Protein ChemistryProteinlipid InteractionProtein AssemblyBiochemistryProtein Folding	2009	130
Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study J. Schiebel, Nedyalka Radeva, S.G. Krimmer, ACS Chemical Biology X-ray CrystallographyHit IdentificationMicroscopyBiomolecular Structure PredictionFragment-based Lead Discovery	2016	125

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