A. Heine

Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib:  New Pharmacological Opportunities Due to Related Binding Site Recognition

Alexander Weber, Angela Casini, A. Heine et al. · Journal of Medicinal Chemistry · 2003 · 448 citations · Full text

Crystal Structure, Drug Target, Chemoprevention Strategy +17

Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope

Carlos F. Barbas, A. Heine, Guofu Zhong et al. · Science · 1997 · 401 citations

Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution

A. Heine, Grace DeSantis, J.G. Luz et al. · Science · 2001 · 279 citations

Transition States, Enzyme Mechanism, Atomic Resolution +15

Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes

J. Schiebel, Roberto Gaspari, Tobias Wulsdorf et al. · Nature Communications · 2018 · 242 citations · Full text

Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste

Karen Köhler, Alexander Hillebrecht, Johannes Schulze Wischeler et al. · Angewandte Chemie International Edition · 2007 · 178 citations · Full text

Food Chemistry, Saccharin Consumption, Bioorganic Chemistry +11