J.G. Luz

Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution

A. Heine, Grace DeSantis, J.G. Luz et al. · Science · 2001 · 279 citations

Transition States, Enzyme Mechanism, Atomic Resolution +15

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD⁺) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

Xun Zhao, Dagart Allison, Bradley Condon et al. · Journal of Medicinal Chemistry · 2013 · 210 citations · Full text

Crystal Structure, Aldo-keto Reductase, Molecular Regulation +20

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

J.G. Luz, Mingdong Huang, K. Christopher García et al. · The Journal of Experimental Medicine · 2002 · 99 citations · Full text

Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

Stephen Antonysamy, Bradley Condon, Zhanna Druzina et al. · PLoS ONE · 2013 · 94 citations · Full text

Histone Modifications, Crystal Structure, Epigenetic Change +23

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

J.G. Luz, Stephen Antonysamy, Steven L. Kuklish et al. · Journal of Medicinal Chemistry · 2015 · 65 citations · Full text