Bradley Condon

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD⁺) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

Xun Zhao, Dagart Allison, Bradley Condon et al. · Journal of Medicinal Chemistry · 2013 · 210 citations · Full text

Crystal Structure, Aldo-keto Reductase, Molecular Regulation +20

Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

Stephen Antonysamy, Bradley Condon, Zhanna Druzina et al. · PLoS ONE · 2013 · 94 citations · Full text

Histone Modifications, Crystal Structure, Epigenetic Change +23

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

J.G. Luz, Stephen Antonysamy, Steven L. Kuklish et al. · Journal of Medicinal Chemistry · 2015 · 65 citations · Full text

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors

Matthew A. Schiffler, Stephen Antonysamy, Shobha Bhattachar et al. · Journal of Medicinal Chemistry · 2015 · 54 citations · Full text

Pharmacotherapy, Chemical Biology, Experimental Pharmacology +19

Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.

J.G. Luz, Matthew W. Carson, Bradley Condon et al. · Journal of Medicinal Chemistry · 2015 · 37 citations · Full text