J. Schiebel

Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes

J. Schiebel, Roberto Gaspari, Tobias Wulsdorf et al. · Nature Communications · 2018 · 242 citations · Full text

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

J. Schiebel, Nedyalka Radeva, S.G. Krimmer et al. · ACS Chemical Biology · 2016 · 125 citations

X-ray Crystallography, Hit Identification, Microscopy +23

High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits

J. Schiebel, S.G. Krimmer, Karine Röwer et al. · Structure · 2016 · 92 citations · Full text

X-ray Crystallography, Crystal Structure, Fragment Hits +8

Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality

J. Schiebel, Andrew Chang, Hao Lu et al. · Structure · 2012 · 91 citations · Full text

Medical Microbiology, Antimicrobial Susceptibility, Health Sciences +13

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

J. Schiebel, Nedyalka Radeva, Helene Köster et al. · ChemMedChem · 2015 · 69 citations

Drug Target, Hit Identification, Biomolecular Structure Prediction +24