S.G. Krimmer

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

J. Schiebel, Nedyalka Radeva, S.G. Krimmer et al. · ACS Chemical Biology · 2016 · 125 citations

X-ray Crystallography, Hit Identification, Microscopy +23

High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits

J. Schiebel, S.G. Krimmer, Karine Röwer et al. · Structure · 2016 · 92 citations · Full text

X-ray Crystallography, Crystal Structure, Fragment Hits +8

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

S.G. Krimmer, Michael Betz, A. Heine et al. · ChemMedChem · 2014 · 82 citations

Protein Assembly, Organic Chemistry, Thermodynamic Signature Shows +23

Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands

S.G. Krimmer, Jonathan Cramer, Michael Betz et al. · Journal of Medicinal Chemistry · 2016 · 77 citations

Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin Inhibitors

Jonathan Cramer, S.G. Krimmer, A. Heine et al. · Journal of Medicinal Chemistry · 2017 · 45 citations